Job Description

General Summary:The Toxicology Senior Research Fellow acts as the Preclinical Safety Assessment (PSA) lead on Research project teams, cross-site teams and steering committees and is accountable for overall project and often disease area and/or site strategy supporting safety assessment of novel molecules and therapies advancing through the Vertex discovery pipeline into early development. The incumbent functions as part of cross-functional project teams and designs appropriate safety in vivo and in vitro safety studies to support advancement of project compounds/therapies from the candidate nomination stage. The incumbent is also accountable for site safety strategy and plays an integrated role in research site scientific leadership.Key Duties and Responsibilities:Develops a broad and deep understanding of the disease area, target biology and chemical space for all Research programs at their resident site. Applies insight and knowledge to influence research strategy and target selection.Independently develops the strategy for early safety assessment and support for multiple programs from target selection to the VXc milestone and aligns with PSA leadershipCollaborates with cross-functional and cross-site partners to develop safety strategies tailored to the portfolio at their resident site.Acts as a liaison between the project teams and other PSA subfunctions to arrange required studies and profiling assays and communicates results to the project team and site management with appropriate interpretation.Works with PSA study monitors to provide scientific oversight of external studies at CROs/partner organizations and communicates significant findings and study events to supervisors and PSA leadership in a timely manner.Collaborates closely with the program regulatory toxicologists to ensure a smooth transition into development at the VXc milestonePrepares high quality reports and presentations to clearly communicate study plans and results to peers, management and project teamsKeeps up to date with current literature and emerging industry trends in general pharmaceutical toxicology and therapeutics. Participates in relevant continuing education activities and drives own professional development.Acts as an opinion leader and mentor to other toxicologists and cross-disciplinary research scientists.Knowledge and Skills:Subject matter expertise in toxicology and the design and interpretation of in vivo studies in common preclinical speciesIn-depth knowledge of animal husbandry and animal welfare issuesExcellent data processing and statistical skillsExcellent written, verbal communications and influencing skillsMicrosoft Office Suite or equivalent office productivity toolsDABT certification preferredEducation and Experience:Bachelor’s, Master’s or Doctoral degree in life sciences or chemistryBachelors degree and 20 years experience orMasters degree and 15 years experience orPhD and 11 years experienceFlex Designation:Hybrid-Eligible Or On-Site EligibleFlex Eligibility Status:In this Hybrid-Eligible role, you can choose to be designated as:1. Hybrid: work remotely up to two days per week; or select2. On-Site: work five days per week on-site with ad hoc flexibility.Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

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